Is 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine? Is 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine safe for nursing mother and child? Does 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine extracts into breast milk? Does 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine has any long term or short term side effects on infants? Can 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine influence milk supply or can 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine decrease milk supply in lactating mothers?
2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine lactation summary
- DrLact safety Score for 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine usage in lactation
It is a first generation antihistaminic and ethanolamine drug with a markedly sedative and antimuscarinic effect (may inhibit lactation). When associated to phenylephrine it is used for nasal congestion relief. Use a minimal dose. Avoid a long-term use.
Answer by DrLact: About 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine usage in lactation
Small occasional doses of 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine are probably acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.
2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Side Effects in Breastfeeding
There are no reports of infants breastfed during maternal therapy with 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine. In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]
2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Possible Effects in Breastfeeding
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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