Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-982A7M02H5? Is UNII-982A7M02H5 safe for nursing mother and child? Does UNII-982A7M02H5 extracts into breast milk? Does UNII-982A7M02H5 has any long term or short term side effects on infants? Can UNII-982A7M02H5 influence milk supply or can UNII-982A7M02H5 decrease milk supply in lactating mothers?

UNII-982A7M02H5 lactation summary

UNII-982A7M02H5 usage has low risk in breastfeeding
  • DrLact safety Score for UNII-982A7M02H5 is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of UNII-982A7M02H5 may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that UNII-982A7M02H5 may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of UNII-982A7M02H5 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using UNII-982A7M02H5 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-982A7M02H5 usage in lactation

It is a first generation antihistaminic and ethanolamine drug with a markedly sedative and antimuscarinic effect (may inhibit lactation). When associated to phenylephrine it is used for nasal congestion relief. Use a minimal dose. Avoid a long-term use.

Answer by DrLact: About UNII-982A7M02H5 usage in lactation

Small occasional doses of UNII-982A7M02H5 are probably acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.

UNII-982A7M02H5 Side Effects in Breastfeeding

There are no reports of infants breastfed during maternal therapy with UNII-982A7M02H5. In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention.[1]

UNII-982A7M02H5 Possible Effects in Breastfeeding

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of UNII-982A7M02H5 have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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