Question

I am a breastfeeding mother and i want to know if it is safe to use R 3746? Is R 3746 safe for nursing mother and child? Does R 3746 extracts into breast milk? Does R 3746 has any long term or short term side effects on infants? Can R 3746 influence milk supply or can R 3746 decrease milk supply in lactating mothers?

Answer by DrLact: About R 3746 usage in lactation

Limited information indicates that R 3746 produces low levels in milk and is not be expected to cause any adverse effects in breastfed infants.. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. R 3746 is acceptable in nursing mothers.

R 3746 Possible Effects in Breastfeeding

Hyperprolactinemia and bilateral galactorrhea occurred in a nonpregnant, 40-year-old woman taking R 3746 200 mg twice daily for 2 days. Seven days after stopping the drug, galactorrhea ceased and the serum prolactin dropped markedly into the normal range. One month later it had dropped further. Because no other cause could be found, the authors determined that the galactorrhea and hyperprolactinemia were probably caused by R 3746.[1] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

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