Question

I am a breastfeeding mother and i want to know if it is safe to use Cefuroxime? Is Cefuroxime safe for nursing mother and child? Does Cefuroxime extracts into breast milk? Does Cefuroxime has any long term or short term side effects on infants? Can Cefuroxime influence milk supply or can Cefuroxime decrease milk supply in lactating mothers?

Cefuroxime lactation summary

Cefuroxime is safe in breastfeeding
  • DrLact safety Score for Cefuroxime is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Cefuroxime is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Cefuroxime does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Cefuroxime safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Cefuroxime usage in lactation

Second-generation cephalosporin for oral and injection or parenteral administration. Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Voropaeva 1982, Amiraslanova 1985, Nakamura 1987). No adverse effects reported in breasted infants (Benyamini 2005). Intravenously administered Cefuroxime salt is not orally absorbed. Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant. Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Answer by DrLact: About Cefuroxime usage in lactation

Limited information indicates that cefuroxime produces low levels in milk that are not expected to cause severe adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Cefuroxime is acceptable in nursing mothers.

Cefuroxime Side Effects in Breastfeeding

A prospective, controlled study asked mothers who called an information service about adverse reactions experience by their breastfed infants. Mothers were taking either cephalexin or cefuroxime. No statistical difference was found in the rate of adverse reactions in the 2 groups, with 1 case of diarrhea in each. This amounted to 2.6% of the cefuroxime-exposed infants.[6]

Alternate Drugs

Methicillin(Low Risk)
Cefdinir(Safe)
Quinine(Safe)
Saquinavir(Unsafe)
Efavirenz(Unsafe)
Aztreonam(Safe)
Ofloxacin(Safe)
Primaquine(Low Risk)
Didanosine(Unsafe)
Gatifloxacin(Low Risk)
Meropenem(Safe)
Cefazolin(Safe)
Atovaquone(Low Risk)
Malathion(Low Risk)
Ritonavir(Unsafe)
Linezolid(Low Risk)
Enoxacin(Low Risk)
Cefprozil(Safe)
Naftifine(Safe)
Abacavir(Safe)
Doxycycline(Low Risk)
Nevirapine(Low Risk)
Dapsone(Low Risk)
Neomycin(Safe)
Cefixime(Safe)
Nelfinavir(Unsafe)
Lomefloxacin(Low Risk)
Cefaclor(Safe)
Capreomycin(Low Risk)
Famciclovir(Low Risk)
Rifaximin(Safe)
Levofloxacin(Low Risk)
Nafcillin(Safe)
Cefepime(Safe)
Erythromycin(Low Risk)
Demeclocycline(Low Risk)
Amikacin(Safe)
Ertapenem(Safe)
Cefoxitin(Safe)
Indinavir(Unsafe)
Kanamycin(Safe)
Zidovudine(Low Risk)
Moxifloxacin(Low Risk)
Clindamycin(Low Risk)
Valganciclovir(Low Risk)
Econazole(Safe)
Amantadine(Low Risk)
Tenofovir(Safe)
Ganciclovir(Low Risk)
Cefotetan(Safe)
Lindane(Unsafe)
Acyclovir(Safe)
Aztreonam(Safe)
Methenamine(Unsafe)
Ofloxacin(Safe)
Gatifloxacin(Low Risk)
Cefazolin(Safe)
Enoxacin(Low Risk)
Cefprozil(Safe)
Doxycycline(Low Risk)
Neomycin(Safe)
Cefixime(Safe)
Lomefloxacin(Low Risk)
Mupirocin(Safe)
Cefaclor(Safe)
Capreomycin(Low Risk)
Nalidixic Acid(Low Risk)
Levofloxacin(Low Risk)
Nafcillin(Safe)
Cefepime(Safe)
Erythromycin(Low Risk)
Demeclocycline(Low Risk)
Ertapenem(Safe)
Iodine(Unsafe)
Cefoxitin(Safe)
Kanamycin(Safe)
Moxifloxacin(Low Risk)
Clindamycin(Low Risk)
Amikacin(Safe)
Cefotetan(Safe)
Methicillin(Low Risk)
Cefdinir(Safe)
Cefazolin(Safe)
Cefprozil(Safe)
Cefixime(Safe)
Cefaclor(Safe)
Cefepime(Safe)
Cefoxitin(Safe)
Cefotetan(Safe)
Cefdinir(Safe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.