Is Cephuroxime Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Cephuroxime? Is Cephuroxime safe for nursing mother and child? Does Cephuroxime extracts into breast milk? Does Cephuroxime has any long term or short term side effects on infants? Can Cephuroxime influence milk supply or can Cephuroxime decrease milk supply in lactating mothers?

Second-generation cephalosporin for oral and injection or parenteral administration. Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Voropaeva 1982, Amiraslanova 1985, Nakamura 1987). No adverse effects reported in breasted infants (Benyamini 2005). Intravenously administered Cephuroxime salt is not orally absorbed. Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant. Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Limited information indicates that Cephuroxime produces low levels in milk that are not expected to cause severe adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Cephuroxime is acceptable in nursing mothers.

A prospective, controlled study asked mothers who called an information service about adverse reactions experience by their breastfed infants. Mothers were taking either cephalexin or Cephuroxime. No statistical difference was found in the rate of adverse reactions in the 2 groups, with 1 case of diarrhea in each. This amounted to 2.6% of the Cephuroxime-exposed infants.[6]