Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-O1R9FJ93ED? Is UNII-O1R9FJ93ED safe for nursing mother and child? Does UNII-O1R9FJ93ED extracts into breast milk? Does UNII-O1R9FJ93ED has any long term or short term side effects on infants? Can UNII-O1R9FJ93ED influence milk supply or can UNII-O1R9FJ93ED decrease milk supply in lactating mothers?

UNII-O1R9FJ93ED lactation summary

UNII-O1R9FJ93ED is safe in breastfeeding
  • DrLact safety Score for UNII-O1R9FJ93ED is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of UNII-O1R9FJ93ED is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that UNII-O1R9FJ93ED does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of UNII-O1R9FJ93ED safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-O1R9FJ93ED usage in lactation

Second-generation cephalosporin for oral and injection or parenteral administration. Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Voropaeva 1982, Amiraslanova 1985, Nakamura 1987). No adverse effects reported in breasted infants (Benyamini 2005). Intravenously administered UNII-O1R9FJ93ED salt is not orally absorbed. Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant. Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Answer by DrLact: About UNII-O1R9FJ93ED usage in lactation

Limited information indicates that UNII-O1R9FJ93ED produces low levels in milk that are not expected to cause severe adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. UNII-O1R9FJ93ED is acceptable in nursing mothers.

UNII-O1R9FJ93ED Side Effects in Breastfeeding

A prospective, controlled study asked mothers who called an information service about adverse reactions experience by their breastfed infants. Mothers were taking either cephalexin or UNII-O1R9FJ93ED. No statistical difference was found in the rate of adverse reactions in the 2 groups, with 1 case of diarrhea in each. This amounted to 2.6% of the UNII-O1R9FJ93ED-exposed infants.[6]

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