Is 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid? Is 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid safe for nursing mother and child? Does 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid extracts into breast milk? Does 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid has any long term or short term side effects on infants? Can 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid influence milk supply or can 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid decrease milk supply in lactating mothers?

First-generation cephalosporin. Oral administration. Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Kafetzis 1981, Matsuda 1984, Ilett 2006). Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant. Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora. 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid is not excreted in significant amount into breast milk (Kafetzis 1981, Matsuda 1984, Ilett 2006). Be aware of false negative bacterial cultures in the infant when the mother is on antibiotics. Also, diarrheal disease due to imbalance of intestinal flora is possible (Ito 1993, Benyamini 2005). A case of a mother reportedly treated with 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acide and Probenecid occurred (Ilett 2006).

Limited information indicates that maternal 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid produces low levels in milk that are usually not expected to cause adverse effects in breastfed infants. 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid is an alternative for the treatment of mastitis.[1][2] Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid is acceptable in nursing mothers.

In a prospective follow-up study, 7 nursing mothers reported taking 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid (dosage not specified). Two mothers reported diarrhea in their infants. No rashes or candidiasis were reported among the exposed infants.[6] A prospective, controlled study asked mothers who called an information service about adverse reactions experience by their breastfed infants. One of 11 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid-exposed infants reportedly developed diarrhea during maternal 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid therapy.[7] A woman received intravenous cephalothin 1 g every 6 hours for 3 days. Her breastfed infant had a green liquid stool, severe diarrhea, discomfort and crying. The mother's drug regimen was then changed to oral 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid 500 mg plus oral probenecid 500 mg 4 times daily for another 16 days. The infant continued to have diarrhea during this time. The authors rated the diarrhea as probably related to 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid in milk.[5]