Is Polaronil Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Polaronil? Is Polaronil safe for nursing mother and child? Does Polaronil extracts into breast milk? Does Polaronil has any long term or short term side effects on infants? Can Polaronil influence milk supply or can Polaronil decrease milk supply in lactating mothers?
Polaronil lactation summary
- DrLact safety Score for Polaronil is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Polaronil may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Polaronil may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Polaronil low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Polaronil We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Polaronil usage in lactation
First generation antihistaminic and alchylamine drug, with sedative effect. Its active isomer is Dexchlorfeniramine. Likely inhibition of lactation within the first weeks post delivery because anti-prolactin effect.. Short-term and low dose (2 mg one or twice-day) treatment is compatible with breastfeeding. Be aware of somnolence in the child. For long-term treatment an alternative drug should be preferred. Compounds in association with expectorants, corticoids and cough relief medicines are available. Avoid drug associations especially while breastfeeding. Follow-up for sedation and feeding ability of the infant. Bed-sharing is not recommended for mothers who are taking this medication.
Answer by DrLact: About Polaronil usage in lactation
Small (2 to 4 mg), occasional doses of Polaronil are acceptable during breastfeeding. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as spseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives, though.
Polaronil Side Effects in Breastfeeding
In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to Polaronil in breastmilk.[1]
Polaronil Possible Effects in Breastfeeding
DexPolaronil in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by dexPolaronil pretreatment of postpartum mothers.[2] Whether lower oral doses of Polaronil have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.
Alternate Drugs
Hydroxyzine(Safe)
Doxylamine(Unsafe)
Fexofenadine(Safe)
Cyclizine(Low Risk)
Diphenhydramine(Low Risk)
Dimenhydrinate(Low Risk)
Levocetirizine(Low Risk)
Dexchlorpheniramine(Low Risk)
Ketotifen(Low Risk)
Desloratadine(Safe)
Meclizine(Low Risk)
Clemastine(Low Risk)
Epinastine(Low Risk)
Chlorpheniramine(Low Risk)
Triprolidine(Safe)
Cetirizine(Safe)
Carbinoxamine(Low Risk)
Pyrilamine(Low Risk)
Brompheniramine(Low Risk)
Azelastine(Low Risk)
Loratadine(Safe)
Acrivastine(Low Risk)