Is Paliperidone Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Paliperidone? Is Paliperidone safe for nursing mother and child? Does Paliperidone extracts into breast milk? Does Paliperidone has any long term or short term side effects on infants? Can Paliperidone influence milk supply or can Paliperidone decrease milk supply in lactating mothers?
Paliperidone lactation summary
- DrLact safety Score for Paliperidone is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Paliperidone is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Paliperidone does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Paliperidone safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Paliperidone usage in lactation
Risperidone and its metabolite (Paliperidone) are excreted into breast milk in non-significant amount. Untoward effect has not been observed on breastfed infants of treated mothers. Serum levels were very low or undetectable in these infants. May be a cause of galactorrhea. Thera are two types of Paliperidone: oral and intramuscular (Depo). Depo type (Paliperidone Palmitate) requires intramuscular administration with a Time to Max of 13 days and a Half-time of 25 to 50 days. That would be a reason to use during breastfeeding a non-depot (oral) medication like Risperidone or any suggested alternative, as a safer choice.
Answer by DrLact: About Paliperidone usage in lactation
Although no data are available for the use of paliperidone during breastfeeding, it is the active metabolite of risperidone. Risperidone data indicate that the concentrations of paliperidone (9-hydroxyrisperidone) in breastmilk are low, and amounts ingested by the infant are small. Because there is no published experience with paliperidone during breastfeeding and little long-term follow-up data, other agents may be preferred, especially while nursing a newborn or preterm infant. Because paliperidone is available only as a sustained-release product, timing of nursing with respect to doses would not be useful.
Paliperidone Side Effects in Breastfeeding
No published information on paliperidone was found as of the revision date. However, limited data from the use of its parent drug, risperidone, during nursing indicate no short- or long-term adverse effects on the infant.[3][4][5]
Paliperidone Possible Effects in Breastfeeding
Paliperidone has caused elevated prolactin serum levels, gynecomastia, and galactorrhea in patients taking the drug.[6][7][8][9][10][11] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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