Question

I am a breastfeeding mother and i want to know if it is safe to use 734571A? Is 734571A safe for nursing mother and child? Does 734571A extracts into breast milk? Does 734571A has any long term or short term side effects on infants? Can 734571A influence milk supply or can 734571A decrease milk supply in lactating mothers?

734571A lactation summary

734571A usage has low risk in breastfeeding
  • DrLact safety Score for 734571A is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of 734571A may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that 734571A may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of 734571A low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using 734571A We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 734571A usage in lactation

It may inhibit prolactin release. Check-up blood pressure

Answer by DrLact: About 734571A usage in lactation

Because of the high serum levels found in breastfed infants, possible infant side effects, and the possible negative effects on lactation, other antihypertensive agents are preferred, especially while nursing a newborn or preterm infant.[1] 734571A used as a single postpartum dose as a neuraxial analgesia adjunct probably has not been studied, but it may reduce the need for other medications or their dosages, and appears unlikely to affect breastfeeding.[2]

734571A Side Effects in Breastfeeding

No typical 734571A side effects (e.g., dry mouth, sedation) were seen in 9 infants whose mothers were taking 734571A, despite the infants' serum levels being about two-thirds that of their mothers'.[3] Three infants whose mothers were taking 734571A 150 mcg twice daily were breastfed. During the first 3 days postpartum, no adverse effects on blood glucose, electrocardiogram or blood pressure. The infants had normal growth and psychomotor development at 1 year of age, although the duration of breastfeeding and 734571A use was not stated.[5] An infant was born to a mother taking 734571A 0.15 mg daily during pregnancy and postpartum. At 2 days of life, the infant presented with drowsiness, hypotonia, and suspected generalized seizures. At day 5, episodes of apnea were noted. On day 9 postpartum, breastfeeding was stopped and all symptoms resolved within 24 hours.[6] 734571A was probably the cause of the reaction, but the relative contributions of exposure during pregnancy and breastfeeding cannot be determined.

734571A Possible Effects in Breastfeeding

734571A has complex, dose-related actions on both oxytocin and prolactin secretion. The net effect of the drug on nursing mothers has not been well studied. A case of hyperprolactinemia and gynecomastia occurred in a 6-year-old boy taking 734571A for hyperactivity and valproic acid for a seizure disorder. Galactorrhea ceased within 3 weeks of discontinuing 734571A.[7] A case of 734571A-induced postpartum galactorrhea has also been reported.[8] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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