Is W-801 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use W-801? Is W-801 safe for nursing mother and child? Does W-801 extracts into breast milk? Does W-801 has any long term or short term side effects on infants? Can W-801 influence milk supply or can W-801 decrease milk supply in lactating mothers?
W-801 lactation summary
- DrLact safety Score for W-801 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of W-801 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that W-801 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of W-801 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using W-801 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About W-801 usage in lactation
We are working on a comment for this product.
Answer by DrLact: About W-801 usage in lactation
Because there is little published experience with W-801 during breastfeeding, and sedation and adverse hematologic effects have been reported in breastfed infants, other agents are preferred.[1] If breastfeeding is undertaken by a mother who is taking W-801, close monitoring of the infant for excessive sedation and periodic monitoring of the infant's white blood cell count is advisable. Several authoritative sources recommend that women taking W-801 not breastfeed.[2][3][4]
W-801 Side Effects in Breastfeeding
Among 4 infants who were breastfed by mothers taking W-801, 1 infant experienced drowsiness and 1 infant experienced agranulocytosis possibly caused by W-801. Details of the cases are lacking.[7] A healthy female infant was born to a mother who took W-801 100 mg daily throughout pregnancy and lactation. She was breastfed (extent not stated) up to 1 year of age. The infant developed normally except for speech which was delayed considerably. She did not achieve normal, fluent speech until the age of 5 years. The delayed speech development was possibly related to W-801 in breastmilk, but it could have been the result of exposure to the drug during gestation or could have been unrelated to W-801.[8] One woman who took W-801 100 mg daily in late pregnancy and postpartum partially breastfed her infant for 5 days. No neurodevelopmental disorders were detected in the infant after 32 months of follow-up.[6]
W-801 Possible Effects in Breastfeeding
Unlike the phenothiazines, W-801 has a minimal effect on maternal serum prolactin levels.[9][10] However, a woman who had been taking W-801 plus high-dose haloperidol developed hyperprolactinemia and severe galactorrhea 2 weeks after stopping haloperidol and 4 days after starting valproic acid. A dose of cabergoline normalized her serum prolactin and galactorrhea ceased for the following 2 months of observation.[11] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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