Is EINECS 227-313-7 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use EINECS 227-313-7? Is EINECS 227-313-7 safe for nursing mother and child? Does EINECS 227-313-7 extracts into breast milk? Does EINECS 227-313-7 has any long term or short term side effects on infants? Can EINECS 227-313-7 influence milk supply or can EINECS 227-313-7 decrease milk supply in lactating mothers?

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Because there is little published experience with EINECS 227-313-7 during breastfeeding, and sedation and adverse hematologic effects have been reported in breastfed infants, other agents are preferred.[1] If breastfeeding is undertaken by a mother who is taking EINECS 227-313-7, close monitoring of the infant for excessive sedation and periodic monitoring of the infant's white blood cell count is advisable. Several authoritative sources recommend that women taking EINECS 227-313-7 not breastfeed.[2][3][4]

Among 4 infants who were breastfed by mothers taking EINECS 227-313-7, 1 infant experienced drowsiness and 1 infant experienced agranulocytosis possibly caused by EINECS 227-313-7. Details of the cases are lacking.[7] A healthy female infant was born to a mother who took EINECS 227-313-7 100 mg daily throughout pregnancy and lactation. She was breastfed (extent not stated) up to 1 year of age. The infant developed normally except for speech which was delayed considerably. She did not achieve normal, fluent speech until the age of 5 years. The delayed speech development was possibly related to EINECS 227-313-7 in breastmilk, but it could have been the result of exposure to the drug during gestation or could have been unrelated to EINECS 227-313-7.[8] One woman who took EINECS 227-313-7 100 mg daily in late pregnancy and postpartum partially breastfed her infant for 5 days. No neurodevelopmental disorders were detected in the infant after 32 months of follow-up.[6]

Unlike the phenothiazines, EINECS 227-313-7 has a minimal effect on maternal serum prolactin levels.[9][10] However, a woman who had been taking EINECS 227-313-7 plus high-dose haloperidol developed hyperprolactinemia and severe galactorrhea 2 weeks after stopping haloperidol and 4 days after starting valproic acid. A dose of cabergoline normalized her serum prolactin and galactorrhea ceased for the following 2 months of observation.[11] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.