Question

I am a breastfeeding mother and i want to know if it is safe to use MK-4117? Is MK-4117 safe for nursing mother and child? Does MK-4117 extracts into breast milk? Does MK-4117 has any long term or short term side effects on infants? Can MK-4117 influence milk supply or can MK-4117 decrease milk supply in lactating mothers?

MK-4117 lactation summary

MK-4117 is safe in breastfeeding
  • DrLact safety Score for MK-4117 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of MK-4117 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that MK-4117 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of MK-4117 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About MK-4117 usage in lactation

Second generation anti-histaminic and piperidine drug with mild sedative effect. Active metabolite of loratadine. Loratadine is excreted in non-significant amount into breast milk. No side effects were observed in breastfed infants of treated mothers. The British Society of Immunology and Allergy rates it compatible with breastfeeding. The American Academy of Pediatrics rates it compatible with breastfeeding.

Answer by DrLact: About MK-4117 usage in lactation

Because of its expected low milk levels and lack of sedation and anticholinergic effects, maternal use of MK-4117 is unlikely to affect a breastfed infant or milk production. MK-4117 might have a negative effect on lactation in combination with a sympathomimetic agent such as pseudoephedrine.

MK-4117 Possible Effects in Breastfeeding

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.