Is 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)-? Is 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- safe for nursing mother and child? Does 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- extracts into breast milk? Does 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- has any long term or short term side effects on infants? Can 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- influence milk supply or can 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- decrease milk supply in lactating mothers?

First generation alkylamine-antihistamine drug, with sedative effect. Active isomer of Chlorpheniramine. Likely inhibition of lactation within the first weeks of post-natal period because of an anti-prolactin effect. Short-term and low dose treatment is compatible with breastfeeding. Be aware of somnolence in the child. For long-term treatments an alternative drug should be preferred. Compounds in association with expectorants, corticoids and cough relief medicines are commercially available. Avoid drug associations especially while breastfeeding. Follow-up on sedation and feeding ability of the infant. Bed-sharing is not recommended for mothers who are taking this medication.

Small, occasional doses of 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use might cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Relevant published information on 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, no side effects were reported among 5 infants exposed to chlorpheniramine in breastmilk.[1]

2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)- pretreatment of postpartum mothers.[2] Whether lower oral doses of chlorpheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.