Question

I am a breastfeeding mother and i want to know if it is safe to use Ciprofloxacin? Is Ciprofloxacin safe for nursing mother and child? Does Ciprofloxacin extracts into breast milk? Does Ciprofloxacin has any long term or short term side effects on infants? Can Ciprofloxacin influence milk supply or can Ciprofloxacin decrease milk supply in lactating mothers?

Ciprofloxacin lactation summary

Ciprofloxacin is safe in breastfeeding
  • DrLact safety Score for Ciprofloxacin is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Ciprofloxacin is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Ciprofloxacin does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Ciprofloxacin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Ciprofloxacin usage in lactation

Quinolone-related medication has been used in neonates and infants without known side effects. It is excreted in tiny amounts into breast milk. Absorption through the child’s gut may be interfered by calcium in the milk. Should it be prescribed to a nursing mother Norfloxacine, Ofloxacine and Ciprofloxacine are to be chosen since they have shown a lowest excretion into the milk. One case of pseudomembranose colitis, possibly related to mother ingestion of Ciporfloxacine, in a premature infant has been described who previously was affected of NEC, Follow-up for diarrhea in the infant is warranted. Be aware of false negative bacterial cultures in the infant when the mother is on antibiotics. The American Academy of Pediatrics rates it compatible with breastfeeding.

Answer by DrLact: About Ciprofloxacin usage in lactation

Amounts of ciprofloxacin in breastmilk are low. Fluoroquinolones such as ciprofloxacin have traditionally not been used in infants because of concern about adverse effects on the infants' developing joints. However, studies indicate little risk.[1] The calcium in milk might decrease absorption of the small amounts of fluoroquinolones in milk,[2] but, insufficient data exist to prove or disprove this assertion. Use of ciprofloxacin is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash). Avoiding breastfeeding for 3 to 4 hours after a dose should decrease the exposure of the infant to ciprofloxacin in breastmilk. Maternal use of an ear drop or eye drop that contains ciprofloxacin presents negligible risk for the nursing infant. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Ciprofloxacin Side Effects in Breastfeeding

A case of pseudomembranous colitis in a 2-month-old breastfed infant with a history of necrotizing enterocolitis was probably caused by maternal self-treatment with ciprofloxacin.[6] Ciprofloxacin was used as part of multi-drug regimens to treat three pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their three infants were breastfed (extent and duration not stated). At age 1.25, 1.8 and 3.9 years, the children were developing normally except for one who had failure to thrive, possibly due to tuberculosis contracted after birth.[7]

Alternate Drugs

Cefoxitin(Safe)
Abacavir(Safe)
Nevirapine(Low Risk)
Cefazolin(Safe)
Enoxacin(Low Risk)
Naftifine(Safe)
Nelfinavir(Unsafe)
Moxifloxacin(Low Risk)
Cefotetan(Safe)
Levofloxacin(Low Risk)
Rifaximin(Safe)
Doxycycline(Low Risk)
Ofloxacin(Safe)
Dapsone(Low Risk)
Valganciclovir(Low Risk)
Famciclovir(Low Risk)
Capreomycin(Low Risk)
Kanamycin(Safe)
Cefaclor(Safe)
Ganciclovir(Low Risk)
Amikacin(Safe)
Indinavir(Unsafe)
Methicillin(Low Risk)
Ertapenem(Safe)
Erythromycin(Low Risk)
Demeclocycline(Low Risk)
Zidovudine(Low Risk)
Clindamycin(Low Risk)
Econazole(Safe)
Amantadine(Low Risk)
Meropenem(Safe)
Tenofovir(Safe)
Cefixime(Safe)
Lindane(Unsafe)
Neomycin(Safe)
Acyclovir(Safe)
Cefepime(Safe)
Quinine(Safe)
Efavirenz(Unsafe)
Saquinavir(Unsafe)
Primaquine(Low Risk)
Cefprozil(Safe)
Didanosine(Unsafe)
Aztreonam(Safe)
Malathion(Low Risk)
Gatifloxacin(Low Risk)
Atovaquone(Low Risk)
Nafcillin(Safe)
Linezolid(Low Risk)
Lomefloxacin(Low Risk)
Ritonavir(Unsafe)
Cefdinir(Safe)
Cefoxitin(Safe)
Cefazolin(Safe)
Enoxacin(Low Risk)
Moxifloxacin(Low Risk)
Cefotetan(Safe)
Levofloxacin(Low Risk)
Doxycycline(Low Risk)
Mupirocin(Safe)
Ofloxacin(Safe)
Kanamycin(Safe)
Cefaclor(Safe)
Capreomycin(Low Risk)
Iodine(Unsafe)
Methicillin(Low Risk)
Ertapenem(Safe)
Erythromycin(Low Risk)
Demeclocycline(Low Risk)
Amikacin(Safe)
Methenamine(Unsafe)
Clindamycin(Low Risk)
Cefixime(Safe)
Neomycin(Safe)
Cefepime(Safe)
Cefprozil(Safe)
Aztreonam(Safe)
Nalidixic Acid(Low Risk)
Gatifloxacin(Low Risk)
Nafcillin(Safe)
Lomefloxacin(Low Risk)
Cefdinir(Safe)
Levofloxacin(Low Risk)
Ofloxacin(Safe)
Gatifloxacin(Low Risk)
Lomefloxacin(Low Risk)
Enoxacin(Low Risk)
Moxifloxacin(Low Risk)
Moxifloxacin(Low Risk)
Levofloxacin(Low Risk)
Ofloxacin(Safe)
Nalidixic Acid(Low Risk)
Gatifloxacin(Low Risk)
Lomefloxacin(Low Risk)
Enoxacin(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.