Is Dexlansoprazole Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Dexlansoprazole? Is Dexlansoprazole safe for nursing mother and child? Does Dexlansoprazole extracts into breast milk? Does Dexlansoprazole has any long term or short term side effects on infants? Can Dexlansoprazole influence milk supply or can Dexlansoprazole decrease milk supply in lactating mothers?

R Isomer of Lansoprazole with similar pharmacokinetics. At latest update, relevant information on excretion into breast milk was not found. Due to a high serum-protein-binding capacity, excretion of Lansoprazole into breast milk is non-significant. Since it's neutralized by the acid pH of stomach, capsules with enteric coated granules are used. Because of this, it is thought that the small quantity of Lansoprazole that may reach the breast milk would be neutralized by infant's stomach. In addition, absorption is greatly decreased by the presence of food. Both Omeprazole and Pantoprazole pertain to the same chemical group with similar pharmacokinetics that are excreted in non-significant amount into the breast milk. Medication that has been used for treatment of newborn and premature infants. Hyperprolactinemia and galactorrhea have been reported by the use of such medication, though some authors have failed to show the same findings.

Dexlansoprazole is the -enantiomer of the protein-pump inhibitor, lansoprazole. No information is available on the use of dexlansoprazole or lansoprazole during breastfeeding. However, lansoprazole has been used safely in newborn infants, so it is unlikely that the amount of dexlansoprazole in breastmilk would be harmful.

One case of elevated serum prolactin and galactorrhea was reported in a 21-year-old man taking lansoprazole (the racemic form). When omeprazole was substituted for lansoprazole, the serum prolactin decreased to the normal range and galactorrhea ceased.[1]