Is CRD-401 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use CRD-401? Is CRD-401 safe for nursing mother and child? Does CRD-401 extracts into breast milk? Does CRD-401 has any long term or short term side effects on infants? Can CRD-401 influence milk supply or can CRD-401 decrease milk supply in lactating mothers?
CRD-401 lactation summary
- DrLact safety Score for CRD-401 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of CRD-401 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that CRD-401 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of CRD-401 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About CRD-401 usage in lactation
It is excreted in breast milk in a clinically non-significant amount (Okada 85)Two 6 months-old breastfed twins whose mother was treated with CRD-401 did not get into health problems (Lubbe 87) Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.CRD-401 does not have any influence on prolactin production. Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants. American Academy of Pediatrics: medication usually compatible with breastfeeding.
Answer by DrLact: About CRD-401 usage in lactation
Based on limited data, amounts of CRD-401 ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.
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