Question

I am a breastfeeding mother and i want to know if it is safe to use Droperidol? Is Droperidol safe for nursing mother and child? Does Droperidol extracts into breast milk? Does Droperidol has any long term or short term side effects on infants? Can Droperidol influence milk supply or can Droperidol decrease milk supply in lactating mothers?

Droperidol lactation summary

Droperidol usage has low risk in breastfeeding
  • DrLact safety Score for Droperidol is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Droperidol may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Droperidol may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Droperidol low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Droperidol We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Droperidol usage in lactation

No data on transfer into breastmilk are available. Check-up for a sedative effect.

Answer by DrLact: About Droperidol usage in lactation

Because little information is available on the long-term use of droperidol during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Single-dose or short-term use during breastfeeding, such as during surgery, is unlikely to adversely affect the breastfed infant, especially if the infant is older than 2 months.[1] When multiple doses are given to the mother, monitor the infant for drowsiness, especially in younger, exclusively breastfed infants and when using combinations of psychotropic drugs.

Droperidol Side Effects in Breastfeeding

A randomized study compared the breastfed infants born by cesarean section whose mothers received either morphine or morphine plus droperidol by patient-controlled analgesia postoperatively. On days 1 and 2 of life, the infants whose mothers received droperidol had a lower neonatal neurologic and adaptive capacity score (NACS) than those who received morphine only.[2] One breastfed (extent not stated) infant whose mother was taking droperidol had a somewhat decreased intellectual development on testing, but her mother had also taken olanzapine, clonazepam, sertraline, thioridazine and valproic acid while breastfeeding.[3]

Droperidol Possible Effects in Breastfeeding

Hyperprolactinemia has been reported in patients taking long-term droperidol[4][5] and after short-term use during surgical procedures.[6][7] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs

Meclizine(Low Risk)
Droperidol(Low Risk)
Dimenhydrinate(Low Risk)
Promethazine(Low Risk)
Cyclizine(Low Risk)
Doxylamine(Unsafe)
Sulpiride(Safe)
Mesoridazine(Unsafe)
Asenapine(Low Risk)
Loxapine(Unsafe)
Ziprasidone(Unsafe)
Thiothixene(Unsafe)
Fluphenazine(Low Risk)
Thioridazine(Unsafe)
Droperidol(Low Risk)
Clozapine(Low Risk)
Chlorpromazine(Low Risk)
Aripiprazole(Low Risk)
Pimozide(Unsafe)
Droperidol(Low Risk)
Droperidol(Low Risk)
Sulpiride(Safe)
Docusate(Safe)
Cascara Sagrada(Low Risk)
Cimetidine(Low Risk)
Rifaximin(Safe)
Alosetron(Low Risk)
Droperidol(Low Risk)
Bisacodyl(Safe)
Ursodiol(Safe)
Dimenhydrinate(Low Risk)
Senna(Safe)
Cisapride(Safe)
Cyclizine(Low Risk)
Doxylamine(Unsafe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.