Question

I am a breastfeeding mother and i want to know if it is safe to use Ethionamide? Is Ethionamide safe for nursing mother and child? Does Ethionamide extracts into breast milk? Does Ethionamide has any long term or short term side effects on infants? Can Ethionamide influence milk supply or can Ethionamide decrease milk supply in lactating mothers?

Answer by DrLact: About Ethionamide usage in lactation

Minimal information exists on the use of ethionamide during breastfeeding. Although some developmental problems have been reported in two infants exposed to ethionamide in breastmilk, their mothers were also exposed to several drugs during pregnancy and during breastfeeding, so the problems cannot necessarily be attributed to ethionamide. If ethionamide is required by the mother of an older infant, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Ethionamide Side Effects in Breastfeeding

Ethionamide was used as part of multidrug regimens to treat two pregnant women with multidrug-resistant tuberculosis, one throughout pregnancy and postpartum and the other postpartum only. The infants were breastfed (extent and duration not stated). At age 4.6 and 5.1 years, the children were developing normally except for a mild speech delay in one and hyperactivity in the other.[1]
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