I am a breastfeeding mother and i want to know if it is safe to use UNII-8GTS82S83M? Is UNII-8GTS82S83M safe for nursing mother and child? Does UNII-8GTS82S83M extracts into breast milk? Does UNII-8GTS82S83M has any long term or short term side effects on infants? Can UNII-8GTS82S83M influence milk supply or can UNII-8GTS82S83M decrease milk supply in lactating mothers?

UNII-8GTS82S83M lactation summary

UNII-8GTS82S83M usage has low risk in breastfeeding
  • DrLact safety Score for UNII-8GTS82S83M is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of UNII-8GTS82S83M may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that UNII-8GTS82S83M may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of UNII-8GTS82S83M low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using UNII-8GTS82S83M We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-8GTS82S83M usage in lactation

It is a first generation antihistamine drug (Ethanolamine) with a strong sedative effect. A high protein-binding capacity makes difficult an excretion into breast milk in significant amounts in accordance with old studies that had confirmed it. The absorption from ingested mother's milk to the infant's plasma is hampered by a low oral bioavailability. For both, the mother and the infant is safer the use of antihistamine medication with higher safety levels without sedative effect, especially when the child is a premature or younger than 1 month old. Neither a decrease of milk production nor alteration of Prolactin release have been shown with the use of this drug. When used while breastfeeding do it with the lower dose as possible and avoid a long-term use. Check up for feeding difficulty and somnolence in the infant. Bed-sharing with the infant is not recommended for parents who are on this medication.

Answer by DrLact: About UNII-8GTS82S83M usage in lactation

Small, occasional doses of UNII-8GTS82S83M would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

UNII-8GTS82S83M Side Effects in Breastfeeding

In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention. In this study, drowsiness was reported in 1 infant of 12 exposed to UNII-8GTS82S83M in breastmilk.[2]

UNII-8GTS82S83M Possible Effects in Breastfeeding

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of UNII-8GTS82S83M have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed. One woman became dependent on dimenhydrinate (which is 55% UNII-8GTS82S83M) during her first pregnancy and continued to take it in a dose of 150 mg (83 mg UNII-8GTS82S83M) daily while she breastfed her infant for 3 months. The infant did well except for a febrile seizure at 2 years of age, which was probably unrelated to dimenhydrinate. During her second pregnancy, she took dimenhydrinate 300 mg (165 mg UNII-8GTS82S83M) daily during the pregnancy and while breastfeeding her infant for 2 years.[5]
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