Is gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide? Is gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide safe for nursing mother and child? Does gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide extracts into breast milk? Does gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide has any long term or short term side effects on infants? Can gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide influence milk supply or can gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide decrease milk supply in lactating mothers?
gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide lactation summary
- DrLact safety Score for gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide usage in lactation
American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.
Answer by DrLact: About gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide usage in lactation
gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide is sometimes found in the plasma of nursing infants at levels of 7.5-12.5% of the mother's levels. The N-monodesalkylgamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide (NMD) metabolite is more anticholinergic than gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide itself and appears in breastmilk in levels higher than gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide. However, of the cases reported, there are no reports of infant effects. gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide may be used cautiously while breastfeeding when other alternatives are unacceptable. Observe the infant for anticholinergic symptoms. Infant serum concentrations can be monitored if there is any concern about drug-induced adverse effects. Theoretically, gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide might decrease the milk supply.
gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide Side Effects in Breastfeeding
There are reports of 2 infants who were breastfed without complications during maternal gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide use of 500 to 600 mg daily.[1][2] Infant symptoms of crying and restlessness after meals thought by one mother to be caused by gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide in breastmilk were judged to be unrelated by the examining physicians.[3]
Alternate Drugs
Quinidine(Safe)
Lidocaine(Safe)
Propafenone(Low Risk)
Timolol(Safe)
Procainamide(Safe)
Sotalol(Low Risk)
Mexiletine(Safe)
Propranolol(Safe)
Flecainide(Safe)
Disopyramide(Safe)
Diltiazem(Safe)
Nadolol(Unsafe)
Digoxin(Safe)
Metoprolol(Safe)
Amiodarone(Unsafe)
Levobunolol(Low Risk)
Labetalol(Safe)
Bisoprolol(Low Risk)
Atenolol(Unsafe)
Acebutolol(Unsafe)
Verapamil(Safe)