Is Disopiramida Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Disopiramida? Is Disopiramida safe for nursing mother and child? Does Disopiramida extracts into breast milk? Does Disopiramida has any long term or short term side effects on infants? Can Disopiramida influence milk supply or can Disopiramida decrease milk supply in lactating mothers?
Disopiramida lactation summary
- DrLact safety Score for Disopiramida is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Disopiramida is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Disopiramida does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Disopiramida safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Disopiramida usage in lactation
American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.
Answer by DrLact: About Disopiramida usage in lactation
Disopiramida is sometimes found in the plasma of nursing infants at levels of 7.5-12.5% of the mother's levels. The N-monodesalkylDisopiramida (NMD) metabolite is more anticholinergic than Disopiramida itself and appears in breastmilk in levels higher than Disopiramida. However, of the cases reported, there are no reports of infant effects. Disopiramida may be used cautiously while breastfeeding when other alternatives are unacceptable. Observe the infant for anticholinergic symptoms. Infant serum concentrations can be monitored if there is any concern about drug-induced adverse effects. Theoretically, Disopiramida might decrease the milk supply.
Disopiramida Side Effects in Breastfeeding
There are reports of 2 infants who were breastfed without complications during maternal Disopiramida use of 500 to 600 mg daily.[1][2] Infant symptoms of crying and restlessness after meals thought by one mother to be caused by Disopiramida in breastmilk were judged to be unrelated by the examining physicians.[3]
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