Is Asenapine Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Asenapine? Is Asenapine safe for nursing mother and child? Does Asenapine extracts into breast milk? Does Asenapine has any long term or short term side effects on infants? Can Asenapine influence milk supply or can Asenapine decrease milk supply in lactating mothers?
Asenapine lactation summary
- DrLact safety Score for Asenapine is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Asenapine may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Asenapine may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Asenapine low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Asenapine We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Asenapine usage in lactation
On latest update relevant data on breastfeeding was not found. Its high molecular weight and plasma protein binding make excretion into breast milk unlikely as has been shown for other related anti-psychotic compounds.
Answer by DrLact: About Asenapine usage in lactation
Because no information is available on the use of asenapine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Asenapine Possible Effects in Breastfeeding
Galactorrhea has been reported with asenapine.[1] Hyperprolactinemia appears to be the cause of the galactorrhea. The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway. The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs
Zuclopenthixol(Safe)
Mesoridazine(Unsafe)
Loxapine(Unsafe)
Haloperidol(Safe)
Asenapine(Low Risk)
Fluphenazine(Low Risk)
Droperidol(Low Risk)
Clozapine(Low Risk)
Paliperidone(Safe)
Chlorpromazine(Low Risk)
Sulpiride(Safe)
Aripiprazole(Low Risk)
Ziprasidone(Unsafe)
Trifluoperazine(Safe)
Thiothixene(Unsafe)
Thioridazine(Unsafe)
Risperidone(Safe)
Quetiapine(Safe)
Pimozide(Unsafe)
Perphenazine(Safe)
Flupenthixol(Safe)
Olanzapine(Safe)