Is Brimonidine Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Brimonidine? Is Brimonidine safe for nursing mother and child? Does Brimonidine extracts into breast milk? Does Brimonidine has any long term or short term side effects on infants? Can Brimonidine influence milk supply or can Brimonidine decrease milk supply in lactating mothers?

Like most ophthalmologic compounds for topical use a low dose and poor absorption make it compatible with breastfeeding. Systemic absorption is minimal. There have not been problems except when a maternal overdose was absorbed.

Limited information indicates that maternal use of brimonidine 0.2% ophthalmic drops do not adversely affect their nursing infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue. Topical brimonidine gel used to treat rosacea has not been studied during breastfeeding. It is unlikely that the topical gel would affect the breastfed infant, but the manufacturer states that it should not be used during nursing. Until more data are available, an alternative topical agent might be preferred

A woman used brimonidine 0.2%, timolol gel-forming solution 0.5%, dipiverin 0.2%, and dorzolamide 0.5% drops for glaucoma while nursing a newborn. The frequency of medication use and extent of nursing were not stated. All medications were given immediately after nursing with punctal occlusion of the tear duct. The infant's vital signs were closely monitored with no signs of bradycardia or apnea.[1] A woman was using ophthalmic drops containing 0.5% timolol and 0.2% brimonidine twice daily in the right eye for 6 months. During this time, she breastfed her infant (extent not stated) apparently without harm to her infant.[2]