Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-8NZ41MIK1O? Is UNII-8NZ41MIK1O safe for nursing mother and child? Does UNII-8NZ41MIK1O extracts into breast milk? Does UNII-8NZ41MIK1O has any long term or short term side effects on infants? Can UNII-8NZ41MIK1O influence milk supply or can UNII-8NZ41MIK1O decrease milk supply in lactating mothers?

UNII-8NZ41MIK1O lactation summary

UNII-8NZ41MIK1O is safe in breastfeeding
  • DrLact safety Score for UNII-8NZ41MIK1O is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of UNII-8NZ41MIK1O is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that UNII-8NZ41MIK1O does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of UNII-8NZ41MIK1O safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-8NZ41MIK1O usage in lactation

This is a Heparin with low molecular weight There is published evidence of a lack of anti-coagulant activity in the serum of breastfed infants whose mothers were treated with UNII-8NZ41MIK1O. The high molecular weight of the so-called standard or non-fragmented Heparin and others called low weight Heparins makes that excretion into breast milk very unlikely. There is scientific proof on the lack of excretion of Dalteparin into breast milk. In addition, Heparin derived drugs are inactivated in the gut and they are not absorbed at all, hence, oral bioavailability is nil. The risk of Heparin-induced Thrombocytopenia and Osteoporosis is lower with low weight Heparin among treated adults.

Answer by DrLact: About UNII-8NZ41MIK1O usage in lactation

Limited information indicates that maternal UNII-8NZ41MIK1O in doses up to 40 mg daily do not to cause any adverse effects in breastfed infants. Because its large molecular weight of 2000 to 8000 daltons, UNII-8NZ41MIK1O would not be expected to be excreted into breastmilk or to be absorbed from breastmilk by the infant. No special precautions are required.[1]

UNII-8NZ41MIK1O Side Effects in Breastfeeding

Ten women received UNII-8NZ41MIK1O 20 mg and 2 received 40 mg daily by subcutaneous injection from the prepartum to the postpartum period. At 5 to 7 days postpartum, anti-Xa activity (a measurement of UNII-8NZ41MIK1O anticoagulant activity) was undetectable in their 12 completely breastfed term neonates 1.5 to 3 hours after they were breastfed for at least 5 days. No bleeding was detected among the infants during maternal UNII-8NZ41MIK1O therapy.[2] A pregnant woman suffered blood clots in the sinuses and 2 small intracranial hemorrhages at 8 weeks of gestation, followed by status epilepticus. She was treated with UNII-8NZ41MIK1O 40 mg twice daily throughout pregnancy and for 3 months postpartum as well as levetiracetam and lacosamide. Her infant was about 50% breastfed for the first 15 days of life. The infant showed normal development at 7 months of age.[3]
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