Question

I am a breastfeeding mother and i want to know if it is safe to use TNFR:Fc? Is TNFR:Fc safe for nursing mother and child? Does TNFR:Fc extracts into breast milk? Does TNFR:Fc has any long term or short term side effects on infants? Can TNFR:Fc influence milk supply or can TNFR:Fc decrease milk supply in lactating mothers?

TNFR:Fc lactation summary

TNFR:Fc is safe in breastfeeding
  • DrLact safety Score for TNFR:Fc is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of TNFR:Fc is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that TNFR:Fc does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of TNFR:Fc safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About TNFR:Fc usage in lactation

Its higher molecular weight makes it secretion into breast milk unlikely. It is not absorbed by gastrointestinal tract due to its protein structure.

Answer by DrLact: About TNFR:Fc usage in lactation

TNFR:Fc is minimally excreted into breastmilk and poorly absorbed by the infant, which would be expected because of its high molecular weight of approximately 150,000. However, long-term follow-up data on infants breastfed during maternal TNFR:Fc use are not available. The risk of adverse effects in older infants is not known, but thought to be unlikely.[1] Most experts feel that the drug is a low risk to the nursing infant and can be given during breastfeeding.[2][3][4][5][6][7]

TNFR:Fc Side Effects in Breastfeeding

A woman with rheumatoid arthritis began TNFR:Fc 25 mg subcutaneously twice a week at 3 months postpartum and later switched to a dose of 50 mg subcutaneously once a week. Her infant was breastfed (extent not stated) until 6 months of age. The infant was reportedly healthy at 3 years of age.[10] A case-control study of women with chronic arthritic conditions found 5 women who received TNFR:Fc during pregnancy and lactation (extent not stated). No differences were observed in the 5 infants' growth parameters, developmental milestones, vaccinations and diseases in the first year of life compared to those not exposed to the drugs with lactation.[11]

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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.