Is H 154/82 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use H 154/82? Is H 154/82 safe for nursing mother and child? Does H 154/82 extracts into breast milk? Does H 154/82 has any long term or short term side effects on infants? Can H 154/82 influence milk supply or can H 154/82 decrease milk supply in lactating mothers?
H 154/82 lactation summary
- DrLact safety Score for H 154/82 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of H 154/82 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that H 154/82 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of H 154/82 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using H 154/82 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About H 154/82 usage in lactation
At latest update no published data were found on excretion into breast milk. Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.Its high plasma protein binding capacity makes it highly unlikely a passage into milk. It has been described an increased Prolactin plasma level and gynecomastia after using H 154/82. Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.
Answer by DrLact: About H 154/82 usage in lactation
Because no information is available on the use of H 154/82 during breastfeeding, an alternate drug may be preferred.
H 154/82 Possible Effects in Breastfeeding
Relevant published informaation was not found as of the revision date.
Alternate Drugs
Nifedipine(Safe)
Bendroflumethiazide(Unsafe)
Reserpine(Unsafe)
Furosemide(Low Risk)
Levobunolol(Low Risk)
Doxazosin(Safe)
Eprosartan(Low Risk)
Benazepril(Safe)
Ramipril(Low Risk)
Fosinopril(Low Risk)
Bosentan(Low Risk)
Labetalol(Safe)
Minoxidil(Safe)
Guanfacine(Low Risk)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Carvedilol(Low Risk)
Methyldopa(Safe)
Bisoprolol(Low Risk)
Nebivolol(Unsafe)
Enalapril(Safe)
Lisinopril(Low Risk)
Nitrendipine(Safe)
Atenolol(Unsafe)
Nicardipine(Safe)
Valsartan(Low Risk)
Acebutolol(Unsafe)
Timolol(Safe)
Terazosin(Unsafe)
Diltiazem(Safe)
Isradipine(Low Risk)
Sotalol(Low Risk)
Nisoldipine(Low Risk)
Telmisartan(Unsafe)
Indapamide(Low Risk)
Propranolol(Safe)
Prazosin(Unsafe)
Chlorthalidone(Dangerous)
Verapamil(Safe)
Chlorothiazide(Safe)
Nimodipine(Safe)
Losartan(Low Risk)
Captopril(Safe)
Trandolapril(Dangerous)
Hydrochlorothiazide(Safe)
Nadolol(Unsafe)
Irbesartan(Unsafe)
Bumetanide(Low Risk)
Torsemide(Low Risk)
Metoprolol(Safe)
Spironolactone(Safe)
Hydralazine(Safe)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Nitrendipine(Safe)
Nicardipine(Safe)
Diltiazem(Safe)
Isradipine(Low Risk)
Nisoldipine(Low Risk)
Verapamil(Safe)
Nimodipine(Safe)
Cinnarizine(Low Risk)
Nifedipine(Safe)
Minoxidil(Safe)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Sildenafil(Safe)
Nitroglycerin(Safe)
Nitrendipine(Safe)
Nebivolol(Unsafe)
Nicardipine(Safe)
Diltiazem(Safe)
Isradipine(Low Risk)
Nisoldipine(Low Risk)
Verapamil(Safe)
Nimodipine(Safe)
Cinnarizine(Low Risk)
Nifedipine(Safe)
Hydralazine(Safe)