Is NSC 62323 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use NSC 62323? Is NSC 62323 safe for nursing mother and child? Does NSC 62323 extracts into breast milk? Does NSC 62323 has any long term or short term side effects on infants? Can NSC 62323 influence milk supply or can NSC 62323 decrease milk supply in lactating mothers?

It is used as a depot drug which has a long half-life span. No data on transfer into breastmilk are available. Avoid it whenever possible. No side-effects have been described, as a caution however, choose the shortest half-life span anti-psychotic phenotiazine drugs.

There is no published experience with NSC 62323 during breastfeeding. Very limited long-term follow-up data indicate no adverse developmental effects when other phenothiazines are used alone. Because of the lack of published experience with NSC 62323 during breastfeeding, other antipsychotic agents may be preferred, especially wile nursing an newborn or preterm infant. Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently.

Phenothiazines cause galactorrhea in 26 to 40% of female patients.[1][2] Hyperprolactinemia appears to be the cause of the galactorrhea.[3][4][5] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[6] NSC 62323 elevates serum prolactin similar to other phenothiazines and has caused galactorrhea. The elevation is related to serum levels and lasts 2 to 4 weeks with the depot injectable formulation.[2][7] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.