Is Norepinephrine Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Norepinephrine? Is Norepinephrine safe for nursing mother and child? Does Norepinephrine extracts into breast milk? Does Norepinephrine has any long term or short term side effects on infants? Can Norepinephrine influence milk supply or can Norepinephrine decrease milk supply in lactating mothers?

Norepinephrine lactation summary

DrLact safety Score for Norepinephrine is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of Norepinephrine is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that Norepinephrine does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of Norepinephrine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Norepinephrine usage in lactation

It is destroyed within the gastrointestinal tract. Systemically used on CPR, and locally for topical anesthesia, ophtalmic drops (mydriatic) and nasal drops (vasoconstriction).

Answer by DrLact: About Norepinephrine usage in lactation

No information is available on the use of norepinephrine during breastfeeding. Because of its poor oral bioavailability and short half-life, any norepinephrine in milk is unlikely to affect the infant. High intravenous doses of norepinephrine might reduce milk production or milk letdown.

Norepinephrine Possible Effects in Breastfeeding

Relevant published information in nursing mothers was not found as of the revision date. Animal data indicate that norepinephrine can decrease serum prolactin and reduce milk production,[1] as well as inhibit the release of oxytocin, which inhibits milk ejection.[2]