Is Sitagliptin Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Sitagliptin? Is Sitagliptin safe for nursing mother and child? Does Sitagliptin extracts into breast milk? Does Sitagliptin has any long term or short term side effects on infants? Can Sitagliptin influence milk supply or can Sitagliptin decrease milk supply in lactating mothers?
Sitagliptin lactation summary
- DrLact safety Score for Sitagliptin is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Sitagliptin may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Sitagliptin may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Sitagliptin low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Sitagliptin We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Sitagliptin usage in lactation
It promotes pancreatic insulin secretion by inhibiting the DPP-4 enzyme that degrades the intestinal hormone GLP-1 that is activated when eating (Baetta 2011, Scheen 2011).Oral administration, once daily.Very low risk of hypoglycemia. Doses 6 times higher than normal for 10 days or 4 times higher for 28 days do not produce side effects (EMA 2016). The most common side effect is rhinopharyngitis. Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (EMA 2016, Scheen 2011): large volume of distribution, moderately high molecular weight and low liposolubility, make it unlikely that it will pass through to breast milk in significant amounts. Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity. Diet, exercise, and breastfeeding improve blood sugar levels. Among the antidiabetics of this same group, Saxagliptin and Vildagliptin would be preferable due to their short half-life (less than 3 hours). See below the information of these related products:
Answer by DrLact: About Sitagliptin usage in lactation
No information is available on the clinical use of sitagliptin during breastfeeding. If sitagliptin is required by the mother, it is not a reason to discontinue breastfeeding. However, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Saxagliptin has a shorter half-life than the other dipeptidyl-peptidase IV inhibitors and linagliptin is highly protein bound, so these might be better choices among drugs in this class for nursing mothers.
Alternate Drugs
Linagliptin(Low Risk)
Sitagliptin(Low Risk)
Saxagliptin(Low Risk)
Alogliptin(Low Risk)
Linagliptin(Low Risk)
Sitagliptin(Low Risk)
Saxagliptin(Low Risk)
Alogliptin(Low Risk)
Tolbutamide(Safe)
Alogliptin(Low Risk)
Rosiglitazone(Low Risk)
Dulaglutide(Low Risk)
Repaglinide(Unsafe)
Pioglitazone(Low Risk)
Nateglinide(Unsafe)
Linagliptin(Low Risk)
Metformin(Safe)
Liraglutide(Low Risk)
Insulin(Safe)
Glyburide(Safe)
Sitagliptin(Low Risk)
Glipizide(Safe)
Glimepiride(Unsafe)
Empagliflozin(Unsafe)
Chlorpropamide(Low Risk)
Dapagliflozin(Unsafe)
Acetohexamide(Low Risk)
Saxagliptin(Low Risk)
Acarbose(Safe)
Colesevelam(Safe)
Miglitol(Safe)
Dulaglutide(Low Risk)
Linagliptin(Low Risk)
Liraglutide(Low Risk)
Sitagliptin(Low Risk)
Saxagliptin(Low Risk)
Alogliptin(Low Risk)