Is Zoledronic Acid Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Zoledronic Acid? Is Zoledronic Acid safe for nursing mother and child? Does Zoledronic Acid extracts into breast milk? Does Zoledronic Acid has any long term or short term side effects on infants? Can Zoledronic Acid influence milk supply or can Zoledronic Acid decrease milk supply in lactating mothers?
Zoledronic Acid lactation summary
- DrLact safety Score for Zoledronic Acid is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Zoledronic Acid may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Zoledronic Acid may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Zoledronic Acid low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Zoledronic Acid We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Zoledronic Acid usage in lactation
It is composed by bisphosphonates. Most bisphosphonates are acidic compounds that achieve low plasma concentration. Both features make it unlikely excretion into the milk in clinically significant amount. Intestinal absorption of bisphosphonates is very low even during fasting and is considered negligible in the presence of milk due to formation with the calcium of non absorbable compounds. Among bisphosponate preparations, Tiludronate and Zoledronate have the longest half-lives period of elimination and thus they are the less indicated to take while breastfeeding. A latest update no published data were found on excretion in the breast milk. Until more data about this drug regarding breastfeeding is available, safer known alternatives (pamidronate) should be of choice, especially in the neonatal period and in case of prematurity.
Answer by DrLact: About Zoledronic Acid usage in lactation
Because no information is available on the use of zoledronic acid during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of zoledronic acid by a breastfed infant is unlikely.
Alternate Drugs
Risedronate(Low Risk)
Ibandronate(Low Risk)
Alendronate(Low Risk)
Risedronate(Low Risk)
Ibandronate(Low Risk)
Calcitriol(Safe)
Alendronate(Low Risk)
Risedronate(Low Risk)
Ibandronate(Low Risk)
Alendronate(Low Risk)