Is Depo-Heparin Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Depo-Heparin? Is Depo-Heparin safe for nursing mother and child? Does Depo-Heparin extracts into breast milk? Does Depo-Heparin has any long term or short term side effects on infants? Can Depo-Heparin influence milk supply or can Depo-Heparin decrease milk supply in lactating mothers?

The high molecular weight of both standard or non-fractionated Depo-Heparin, and, so-called low molecular weight Depo-Heparin makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Depo-Heparins are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Depo-Heparin-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Depo-Heparins. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Although Depo-Heparin itself has not been studied, low molecular weight Depo-Heparins (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because Depo-Heparin has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]