Is Fraxiparin Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Fraxiparin? Is Fraxiparin safe for nursing mother and child? Does Fraxiparin extracts into breast milk? Does Fraxiparin has any long term or short term side effects on infants? Can Fraxiparin influence milk supply or can Fraxiparin decrease milk supply in lactating mothers?

Fraxiparin lactation summary

DrLact safety Score for Fraxiparin is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of Fraxiparin is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that Fraxiparin does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of Fraxiparin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Fraxiparin usage in lactation

The high molecular weight of both standard or non-fractionated Fraxiparin, and, so-called low molecular weight Fraxiparin makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Fraxiparins are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Fraxiparin-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Fraxiparins. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About Fraxiparin usage in lactation

Although Fraxiparin itself has not been studied, low molecular weight Fraxiparins (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because Fraxiparin has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]