Is Hed-heparin Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Hed-heparin? Is Hed-heparin safe for nursing mother and child? Does Hed-heparin extracts into breast milk? Does Hed-heparin has any long term or short term side effects on infants? Can Hed-heparin influence milk supply or can Hed-heparin decrease milk supply in lactating mothers?

The high molecular weight of both standard or non-fractionated Hed-heparin, and, so-called low molecular weight Hed-heparin makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Hed-heparins are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Hed-heparin-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Hed-heparins. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Although Hed-heparin itself has not been studied, low molecular weight Hed-heparins (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because Hed-heparin has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]