Is Heparin sulfate Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Heparin sulfate? Is Heparin sulfate safe for nursing mother and child? Does Heparin sulfate extracts into breast milk? Does Heparin sulfate has any long term or short term side effects on infants? Can Heparin sulfate influence milk supply or can Heparin sulfate decrease milk supply in lactating mothers?

The high molecular weight of both standard or non-fractionated Heparin sulfate, and, so-called low molecular weight Heparin sulfate makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Heparin sulfates are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Heparin sulfate-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Heparin sulfates. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Although Heparin sulfate itself has not been studied, low molecular weight Heparin sulfates (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because Heparin sulfate has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]