Is HSDB 3094 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use HSDB 3094? Is HSDB 3094 safe for nursing mother and child? Does HSDB 3094 extracts into breast milk? Does HSDB 3094 has any long term or short term side effects on infants? Can HSDB 3094 influence milk supply or can HSDB 3094 decrease milk supply in lactating mothers?

HSDB 3094 lactation summary

DrLact safety Score for HSDB 3094 is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of HSDB 3094 is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that HSDB 3094 does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of HSDB 3094 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About HSDB 3094 usage in lactation

The high molecular weight of both standard or non-fractionated HSDB 3094, and, so-called low molecular weight HSDB 3094 makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, HSDB 3094s are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of HSDB 3094-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight HSDB 3094s. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About HSDB 3094 usage in lactation

Although HSDB 3094 itself has not been studied, low molecular weight HSDB 3094s (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because HSDB 3094 has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]