Is Novoheparin Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Novoheparin? Is Novoheparin safe for nursing mother and child? Does Novoheparin extracts into breast milk? Does Novoheparin has any long term or short term side effects on infants? Can Novoheparin influence milk supply or can Novoheparin decrease milk supply in lactating mothers?

Novoheparin lactation summary

DrLact safety Score for Novoheparin is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of Novoheparin is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that Novoheparin does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of Novoheparin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Novoheparin usage in lactation

The high molecular weight of both standard or non-fractionated Novoheparin, and, so-called low molecular weight Novoheparin makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Novoheparins are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Novoheparin-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Novoheparins. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About Novoheparin usage in lactation

Although Novoheparin itself has not been studied, low molecular weight Novoheparins (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because Novoheparin has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]