Is CY 222 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use CY 222? Is CY 222 safe for nursing mother and child? Does CY 222 extracts into breast milk? Does CY 222 has any long term or short term side effects on infants? Can CY 222 influence milk supply or can CY 222 decrease milk supply in lactating mothers?

CY 222 lactation summary

DrLact safety Score for CY 222 is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of CY 222 is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that CY 222 does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of CY 222 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About CY 222 usage in lactation

The high molecular weight of both standard or non-fractionated CY 222, and, so-called low molecular weight CY 222 makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, CY 222s are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of CY 222-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight CY 222s. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About CY 222 usage in lactation

Although CY 222 itself has not been studied, low molecular weight CY 222s (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because CY 222 has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]