Is Clivarine Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Clivarine? Is Clivarine safe for nursing mother and child? Does Clivarine extracts into breast milk? Does Clivarine has any long term or short term side effects on infants? Can Clivarine influence milk supply or can Clivarine decrease milk supply in lactating mothers?

Clivarine lactation summary

DrLact safety Score for Clivarine is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of Clivarine is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that Clivarine does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of Clivarine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Clivarine usage in lactation

The high molecular weight of both standard or non-fractionated Clivarine, and, so-called low molecular weight Clivarine makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Clivarines are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Clivarine-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Clivarines. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About Clivarine usage in lactation

Although Clivarine itself has not been studied, low molecular weight Clivarines (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because Clivarine has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]