Is Dalteparin Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Dalteparin? Is Dalteparin safe for nursing mother and child? Does Dalteparin extracts into breast milk? Does Dalteparin has any long term or short term side effects on infants? Can Dalteparin influence milk supply or can Dalteparin decrease milk supply in lactating mothers?

This is a Heparin with low molecular weight There is scientific proof on the lack of excretion of Dalteparin into breast milk. The high molecular weight of the so-called Standard or non-fragmented Heparin and others called low weight Heparins makes that excretion into breast milk very unlikely. There is published evidence of a lack of anti-coagulant activity in the serum of breastfed infants whose mothers were treated with Enoxaparin. In addition, Heparin derived drugs are inactivated in the gut and they are not absorbed at all, hence, oral bioavailability is nil. The risk of Heparin-induced Thrombocytopenia and Osteoporosis is lower with low weight Heparin among treated adults.

Because of the low levels of dalteparin in breastmilk and its large molecular weight of 2000 to 9000 daltons, amounts ingested by the infant are small and it would not be expected to be absorbed from breastmilk by the infant. No special precautions are required.[1]

Although not clearly stated, it appears that 15 neonates were breastfed during maternal dalteparin use in one study with no adverse effects reported.[3] In another report, one mother breastfed her infant for 20 days starting at 7 weeks of age while taking subcutaneous dalteparin 5000 IU subcutaneously twice daily with no adverse effects to her infant.[4]