Is OP 386 Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use OP 386? Is OP 386 safe for nursing mother and child? Does OP 386 extracts into breast milk? Does OP 386 has any long term or short term side effects on infants? Can OP 386 influence milk supply or can OP 386 decrease milk supply in lactating mothers?

OP 386 lactation summary

DrLact safety Score for OP 386 is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of OP 386 is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that OP 386 does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of OP 386 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About OP 386 usage in lactation

The high molecular weight of both standard or non-fractionated OP 386, and, so-called low molecular weight OP 386 makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, OP 386s are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of OP 386-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight OP 386s. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About OP 386 usage in lactation

Although OP 386 itself has not been studied, low molecular weight OP 386s (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because OP 386 has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]