Is Parnaparin Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Parnaparin? Is Parnaparin safe for nursing mother and child? Does Parnaparin extracts into breast milk? Does Parnaparin has any long term or short term side effects on infants? Can Parnaparin influence milk supply or can Parnaparin decrease milk supply in lactating mothers?

Parnaparin lactation summary

DrLact safety Score for Parnaparin is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of Parnaparin is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that Parnaparin does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of Parnaparin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Parnaparin usage in lactation

The high molecular weight of both standard or non-fractionated Parnaparin, and, so-called low molecular weight Parnaparin makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Parnaparins are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Parnaparin-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Parnaparins. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About Parnaparin usage in lactation

Although Parnaparin itself has not been studied, low molecular weight Parnaparins (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because Parnaparin has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]