Is Subeparin Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Subeparin? Is Subeparin safe for nursing mother and child? Does Subeparin extracts into breast milk? Does Subeparin has any long term or short term side effects on infants? Can Subeparin influence milk supply or can Subeparin decrease milk supply in lactating mothers?

Subeparin lactation summary

DrLact safety Score for Subeparin is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of Subeparin is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that Subeparin does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of Subeparin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Subeparin usage in lactation

The high molecular weight of both standard or non-fractionated Subeparin, and, so-called low molecular weight Subeparin makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Subeparins are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Subeparin-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Subeparins. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About Subeparin usage in lactation

Although Subeparin itself has not been studied, low molecular weight Subeparins (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because Subeparin has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]