Is UNII-1K5KDI46KZ Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-1K5KDI46KZ? Is UNII-1K5KDI46KZ safe for nursing mother and child? Does UNII-1K5KDI46KZ extracts into breast milk? Does UNII-1K5KDI46KZ has any long term or short term side effects on infants? Can UNII-1K5KDI46KZ influence milk supply or can UNII-1K5KDI46KZ decrease milk supply in lactating mothers?
UNII-1K5KDI46KZ lactation summary
- DrLact safety Score for UNII-1K5KDI46KZ is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of UNII-1K5KDI46KZ is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that UNII-1K5KDI46KZ does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of UNII-1K5KDI46KZ safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-1K5KDI46KZ usage in lactation
The high molecular weight of both standard or non-fractionated UNII-1K5KDI46KZ, and, so-called low molecular weight UNII-1K5KDI46KZ makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, UNII-1K5KDI46KZs are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of UNII-1K5KDI46KZ-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight UNII-1K5KDI46KZs. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.
Answer by DrLact: About UNII-1K5KDI46KZ usage in lactation
Although UNII-1K5KDI46KZ itself has not been studied, low molecular weight UNII-1K5KDI46KZs (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because UNII-1K5KDI46KZ has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]
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