Is Adomiparin Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Adomiparin? Is Adomiparin safe for nursing mother and child? Does Adomiparin extracts into breast milk? Does Adomiparin has any long term or short term side effects on infants? Can Adomiparin influence milk supply or can Adomiparin decrease milk supply in lactating mothers?

Adomiparin lactation summary

DrLact safety Score for Adomiparin is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of Adomiparin is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that Adomiparin does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of Adomiparin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Adomiparin usage in lactation

The high molecular weight of both standard or non-fractionated Adomiparin, and, so-called low molecular weight Adomiparin makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, Adomiparins are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of Adomiparin-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight Adomiparins. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About Adomiparin usage in lactation

Although Adomiparin itself has not been studied, low molecular weight Adomiparins (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because Adomiparin has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]