Is UNII-E47C0NF7LV Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-E47C0NF7LV? Is UNII-E47C0NF7LV safe for nursing mother and child? Does UNII-E47C0NF7LV extracts into breast milk? Does UNII-E47C0NF7LV has any long term or short term side effects on infants? Can UNII-E47C0NF7LV influence milk supply or can UNII-E47C0NF7LV decrease milk supply in lactating mothers?

UNII-E47C0NF7LV lactation summary

UNII-E47C0NF7LV is safe in breastfeeding

DrLact safety Score for UNII-E47C0NF7LV is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of UNII-E47C0NF7LV is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that UNII-E47C0NF7LV does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of UNII-E47C0NF7LV safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About UNII-E47C0NF7LV usage in lactation

The high molecular weight of both standard or non-fractionated UNII-E47C0NF7LV, and, so-called low molecular weight UNII-E47C0NF7LV makes excretion into breast milk extremely difficult. Dalteparin has been shown not to be excreted into breast milk . In addition, UNII-E47C0NF7LVs are inactivated in the GE tract where they are not absorbed which is reason to have a nil oral bioavailability. Absence of anti-clotting activity in breastfed infants has been shown after treatment of the mother with Enoxaparin. Risk of UNII-E47C0NF7LV-induced Thrombocytopenia or Osteoporosis in the mother is lower with low weight UNII-E47C0NF7LVs. Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About UNII-E47C0NF7LV usage in lactation

Although UNII-E47C0NF7LV itself has not been studied, low molecular weight UNII-E47C0NF7LVs (e.g., dalteparin, enoxaparin) are not excreted into breastmilk in clinically relevant amounts. Because UNII-E47C0NF7LV has an even higher molecular weight of 3000 to 30,000 daltons, it would not be expected to be appreciably excreted into breastmilk or absorbed by the infant. No special precautions are required.[1]