Question

I am a breastfeeding mother and i want to know if it is safe to use Physostigmine? Is Physostigmine safe for nursing mother and child? Does Physostigmine extracts into breast milk? Does Physostigmine has any long term or short term side effects on infants? Can Physostigmine influence milk supply or can Physostigmine decrease milk supply in lactating mothers?

Answer by DrLact: About Physostigmine usage in lactation

No information is available on the use of physostigmine during breastfeeding.

Physostigmine Possible Effects in Breastfeeding

Relevant published information in nursing mothers was not found as of the revision date. In animals, cholinergic drugs increase oxytocin release,[2] and have variable effects on serum prolactin.[3] Physostigmine increases serum prolactin in humans.[4][5] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs

Echothiophate
Neostigmine
Pyridostigmine(Safe)
Edrophonium
Physostigmine
Carbachol(Low Risk)
Bethanechol(Unsafe)
Acetylcholine
Neostigmine
Pyridostigmine(Safe)
Edrophonium
Physostigmine
Pilocarpine(Unsafe)
Echothiophate

Synonyms of Physostigmine

Antilirium
Calabarine
Carbamic acid, methyl-, ester with eseroline
CCRIS 3422
CS 58525
EINECS 200-332-8
Eserine
Eserolein, methylcarbamate (ester)
Esromiotin
Ezerin
Fysostigmin [Czech]
(3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-ol methylcarbamate (ester)
HSDB 3161
MCV 4484
Methyl-carbamic acid, ester with eseroline
NIH 10421
NSC 30782
Physostol
Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-
Fysostigmin
UNII-9U1VM840SP
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