I am a breastfeeding mother and i want to know if it is safe to use Cyclizine? Is Cyclizine safe for nursing mother and child? Does Cyclizine extracts into breast milk? Does Cyclizine has any long term or short term side effects on infants? Can Cyclizine influence milk supply or can Cyclizine decrease milk supply in lactating mothers?

Cyclizine lactation summary

Cyclizine usage has low risk in breastfeeding
  • DrLact safety Score for Cyclizine is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Cyclizine may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Cyclizine may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Cyclizine low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Cyclizine We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Cyclizine usage in lactation

It is a first generation anti-histaminic and piperazine drug with a moderate sedative effect. Used for vomiting relief. Also associated to other drugs for symptomatic relief of migraine.

Answer by DrLact: About Cyclizine usage in lactation

Occasional doses of cyclizine are probably acceptable during breastfeeding. Large doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established.

Cyclizine Side Effects in Breastfeeding

Relevant published information on cyclizine was not found as of the revision date. In one telephone follow-up study, mothers reported irritability and colicky symptoms 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to cyclizine.[1]

Cyclizine Possible Effects in Breastfeeding

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[2][3] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[2] Whether lower oral doses of antihistamines have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied.

Alternate Drugs

Meclizine(Low Risk)
Omalizumab(Low Risk)
Ketotifen(Low Risk)
Cyclizine(Low Risk)
Meclizine(Low Risk)
Droperidol(Low Risk)
Dimenhydrinate(Low Risk)
Promethazine(Low Risk)
Cyclizine(Low Risk)
Clemastine(Low Risk)
Meclizine(Low Risk)
Carbinoxamine(Low Risk)
Epinastine(Low Risk)
Levocetirizine(Low Risk)
Brompheniramine(Low Risk)
Azelastine(Low Risk)
Diphenhydramine(Low Risk)
Ketotifen(Low Risk)
Acrivastine(Low Risk)
Pyrilamine(Low Risk)
Dimenhydrinate(Low Risk)
Cyclizine(Low Risk)
Alosetron(Low Risk)
Cimetidine(Low Risk)
Cascara Sagrada(Low Risk)
Droperidol(Low Risk)
Dimenhydrinate(Low Risk)
Cyclizine(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.