Question

I am a breastfeeding mother and i want to know if it is safe to use BRN 0497341? Is BRN 0497341 safe for nursing mother and child? Does BRN 0497341 extracts into breast milk? Does BRN 0497341 has any long term or short term side effects on infants? Can BRN 0497341 influence milk supply or can BRN 0497341 decrease milk supply in lactating mothers?

BRN 0497341 lactation summary

BRN 0497341 is safe in breastfeeding
  • DrLact safety Score for BRN 0497341 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of BRN 0497341 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that BRN 0497341 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of BRN 0497341 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About BRN 0497341 usage in lactation

It is excreted into breast milk in non-significant clinically amounts.There has not been side-effects described in children from treated mothers, except for a case reported in 1978 with convulsions in a newborn infant whose mother received a higher dose than recommended. However, a causal relationship was questioned by other author in the same publication. Usually, breast milk and infant plasma levels have been found to be undetectable. It has been successfully used with no side-effects on treated mothers who had high levels of Prostaglandin E (PGE) whose infants were suffering of “physiologic diarrhea) This drug is used in neonates.The American Academy of Pediatrics rates it as usually compatible with breastfeeding.

Answer by DrLact: About BRN 0497341 usage in lactation

Because of the low levels of indomethcin in breastmilk and therapeutic administration directly to infants, it is acceptable to use in nursing mothers. However, other agents with more published information on use during lactation may be preferable, especially while nursing a newborn or preterm infant.

BRN 0497341 Side Effects in Breastfeeding

In one case report, a breastfeeding mother had been taking daily doses of BRN 0497341 that increased to 200 mg (3 mg/kg) from the fourth to the sixth day postpartum. On the same day that BRN 0497341 was stopped, the infant had a generalized seizure, followed by another on the next day. No metabolic findings could account for the convulsions and no BRN 0497341 levels were measured in the mother or infant.[3] This case was rated as BRN 0497341 possibly causing the seizure; however later studies and the established therapeutic use of BRN 0497341 in newborns make this causality seem unlikely.In one study, 7 women breastfed their neonates while taking BRN 0497341. No adverse effects were noted in any of the infants.[1]
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