Is Alglucosidase Alfa Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Alglucosidase Alfa? Is Alglucosidase Alfa safe for nursing mother and child? Does Alglucosidase Alfa extracts into breast milk? Does Alglucosidase Alfa has any long term or short term side effects on infants? Can Alglucosidase Alfa influence milk supply or can Alglucosidase Alfa decrease milk supply in lactating mothers?

Because alglucosidase is a large protein molecule with a molecular weight of about 110,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract Alglucosidase alfa activity was detectable in breastmilk for only 24 hours after a dose in one woman. The investigators recommended withholding breastfeeding for 24 hours after each dose as a precaution until more data are obtained.[1]

An infant was born to a mother receiving alglucosidase alfa during pregnancy and lactation in an intravenous dose of 20 mg/kg every 2 weeks for adult-onset Pompe disease. At 3 and 77 days of age, the infant's serum had negligible anti-alglucosidase alfa antibodies. The infant was examined regularly up to 1 year of age and showed normal development, although the extent of breastfeeding during this time was not stated.[1]